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Dr. Steven Pelech, Ph.D.
Professor, Department of Medicine
Kinexus Bioinformatics Corporation
8755 Ash Street, Suite 1
Vancouver BC Canada V6P 6T3
Tel: (604) 323-2547, ext. 10
Fax: (604) 323-2548
Research Interests: Dr. Pelech’s research is focused on the mapping of protein kinase-based cell signalling pathways to identify diagnostic biomarkers and therapeutic targets for drug development for neurological disorders, cancer and diabetes. Experimental disease model systems under analyses relate to Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, cancer, and diabetes. Other systems under study relate to the regulation of meiotic maturation of oocytes, mitotic cell cycle progression in human tumour cells, and insulin signalling for metabolic control. Dr. Pelech’s lab has developed and utilized novel proteomics strategies involving multi-immunoblotting and microarrays with antibodies, cell/tissue lysates and purified protein kinase enzymes.
1975-1979: B.Sc. (Honours) Biochemistry (University of British Columbia)
1979-1982: Ph.D. Biochemistry (University of British Columbia)
1982-1982: Post-doctoral fellow (University of British Columbia)
1982-1983: Post-doctoral fellow (University of Dundee, Scotland)
1983-1987: Post-doctoral fellow (University of Washington, Seattle)
1987-1998: Senior Scientist, The Biomedical Research Centre
1988-1993: Assistant Professor Medicine, University of British Columbia
1993-1997: Associate Professor Medicine, University of British Columbia
1997-Present: Full Professor of Medicine, University of British Columbia
1992-1998: Founder, President & CEO, Kinetek Pharmaceuticals, Inc.
1998-Present: Senior Scientist, The Brain Research Centre
1999-Present: Founder, President & CSO of Kinexus Bioinformatics Corporation
Honours and Awards:
Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship, Univ. of B.C. (1978)
Medical Research Council (M.R.C.) Canada Studentship, Univ. of B.C. (1979 - 1982)
Univ. of B.C. Graduate Student Speaker Competition, 1st place (1982)
Izaak Walton Killam Postdoctoral Fellowship (1982)
M.R.C. of Canada Postdoctoral Fellowship (1982 - 1984)
M.R.C. of Canada 1967 Centennial Fellowship (1985)
M.R.C. of Canada Scholarship Award (salary support) (1988 - 1993)
Canadian Soc. for Biochem. & Molec. Biol. Merck-Frosst Award - for outstanding research in the area of biochemistry and molecular biology in Canada (1993)
Martin M. Hoffman Award - Univ. of B.C. Hospital Site for Research in Dept. of Medicine (1993)
M.R.C. of Canada Scientist Award (salary support) (1993-1996)
M.R.C. of Canada Industrial Scientist Award (salary support) (1996-1998)
Business in Vancouver Top Forty Under Forty Award for Business Achievement (1996)
Faculty of Medicine 2001 Distinguished Lecturer for Basic Sciences, Univ. of B.C. (2001)
Kinexus Bioinformatics Corporation, Vancouver, B.C. (Board of Directors)
National Research Council of Canada (Genomics and Health Initiative Expert Panel)
Pelech, S. Hitting the right kinase targets. BioForum Europe. (2008, in press).
Pelech, S. Biomarker identification for diagnosis of Alzheimer’s disease. Expert Opin Medical Devices. (2008, in press).
Pelech, S., Jelinkova, L., Susor, A., Zhang, H., Shi, X., Pavlok, A., Kubelka, M., & Kovarova, H., Antibody microarray analyses of signal transduction protein expression and phosphorylation during porcine oocyte maturation. J. Proteomics Res. 7(7):2860-71. (2008). [Epub 2008 May 17]. [PubMed]
Skalnikova, H., Vodicka, P., Pelech, S., Motlik, J., Gadher, S.J., Kovarova, H. Protein signalling pathways in differentiation of neural stem cells. Proteomics. (2008 Oct 7.) [Epub ahead of print]. [PubMed]
Lu, C., Pelech, S., Zhang, H., Bond, J., Spach, K., Blankenhorn, E. P., & Teuscher, C. Pertusis toxin induces angiogenesis in brain microvascular endothelial cells. J. Neurosci. Res. 86(12):2624-40 (2008). [PubMed]
Ren, H. Erber, R., Giese, A., Pelech, S., Chou, T.C., Walker, C., Pazmany, L., & Rainov, N.G. Biological activity of the 2-phenylaminopyrimidine class receptor tyrosine kinase inhibitor Imatinib (STI571) in malignant glioma. J. Neuro-Oncology (2008, in press).
Parkhouse, W.S., Cunningham, L., McFee, I., Litt Miller, J.M., Whitney, D., Pelech, S. L., & Krieger, C. Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. 9:24-34 (2008). [PubMed]
Fan, M. Y., Zhang, H., Hayden, M. R., Pelech, S. L., & Raymond, L. A. Protein expression profiling in cells co-expressing N-methyl-D-aspartate receptors and mutant huntingtin: upregulation of protective stress response pathway. J. Neurochem. 104:790-805 (2008). [PubMed]
Pelech, S.L. and Zhang, H. Antibody-based proteomics analysis of tumour cell signaling pathways. Principles of Molecular Oncology, Third Edition (Edited by M.H. Bronchud, Humana Press Inc., Totowa, NJ (2007, in press).
Ha, S.-D., Ng, D., Pelech, S.L., & Kim, S.O. Critical role of PI3-K/Akt/GSK3b signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in human monocytic cell lines. J. Biol. Chem. 282:36230-36239 (2007). [PubMed]
Oh, W.-J., Rishi, V., Pelech, S.L., & Vinson, C. Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin. Carcinogenesis 28:2244-2252 (2007). [PubMed]
Hoerndli, F.J., Pelech, S, , Papassotiropoulos, A., & Gotz, J. Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry. Eur. J. Neurosci. 26:60-72 (2007). [PubMed]
Pelech, S.L. Protein kinase profiling. Commentary: Nature Biotechnology. September (2006).
Pelech, S.L. Kinase Profiling; The mysteries unraveled. Future Pharmaceuticals. 1:23-25 (2006).
Pelech, S. Dimerization in protein kinase signaling. J Biol. 19; 5(5): 12 (2006). [PubMed]
Klergis, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. Alpha-synuclein activates stress signaling protein kinases in THP cells and microglial. Neurobiology of Aging 29:739-752 (2008). (Epub 2006 Dec 11). [PubMed]
Klegeris, A., Giasson, B. I., Zhang, H., Maguire, J., Pelech, S., & McGeer, P. L. Alpha-synuclein and its disease-causing mutants induce ICAM‑1 and IL-6 in human astrocytes and astrocytoma cells. FASEB J. 20:2000-2008 (2006). [PubMed]
Shi, X., Zhang, H., Paddon, H.B., Lee, G. & Pelech, S.L. Phosphorylation of STAT3 serine 727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest. Biochemistry 45:5857-5867 (2006). [PubMed]
Lipinski, K.S., Pelech, S., Mountain, A., Irvine, A.S., Kraaij, R., Bangma, C., Mills, K.H.G., and Todryk, S.M. Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity. Cancer Immunol Immunother. 55:347-354 (2006). [PubMed]